Juvenile xanthogranuloma - Xantogranuloma Juvenil
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Nos resultados do Stiftung Warentest de 2022 da Alemanha, a satisfação do consumidor com o ModelDerm foi apenas ligeiramente inferior do que com as consultas pagas de telemedicina.
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ReferencesJuvenile xanthogranuloma (JXG) é uma condição bastante comum e o tipo mais frequente de non‑Langerhans cell histiocytic disorder em crianças. Em cerca de 75 % dos casos, as lesões aparecem no primeiro ano de vida, e mais de 15 % a 20 % dos pacientes as apresentam desde o nascimento. Embora raro em adultos, o JXG geralmente ocorre com mais frequência em pessoas entre 20 e 30 anos, e a maioria dos pacientes adultos apresenta apenas uma lesão. Clinicamente, aparece como protuberâncias ou nódulos firmes, únicos ou múltiplos, de coloração amarelo‑laranja‑marrom, principalmente na face, pescoço e parte superior do corpo. Lesões orais são incomuns, mas podem manifestar‑se como um nódulo amarelo nas laterais da língua ou em outras áreas da boca, possivelmente causando úlceras e sangramento. As lesões cutâneas geralmente não causam sintomas e tendem a desaparecer espontaneamente ao longo de vários anos. Embora raro, o envolvimento ocular é o problema mais comum além da pele, seguido pelo envolvimento pulmonar. Ocular JXG normalmente afeta apenas um olho e ocorre em menos de 0,5 % dos pacientes, embora cerca de 40 % daqueles com envolvimento ocular também apresentem múltiplas lesões cutâneas no momento do diagnóstico.
Juvenile xanthogranuloma (JXG) is a relatively common entity and is the most common form of non-Langerhans cell histiocytic disorder of childhood., It is estimated that in 75% of cases, lesions appear during the first year of life, with >15-20% of patients having lesions at birth. JXG is rare in adults, with a peak incidence in the late twenties to thirties. The majority of adult patients have solitary lesions. Typically, the clinical presentation consists of solitary or multiple yellow-orange-brown firm papules or nodules. The most common locations are the face, neck, and upper torso. Oral lesions are rare and often occur as a yellow nodule on the lateral aspects of the tongue. Oral lesions can also arise on the gingival, buccal mucosa, and midline hard palate and may ulcerate and bleed. Cutaneous lesions are usually asymptomatic, and most lesions spontaneously involute over the course of several years. Although occurring rarely, ocular involvement is the most common extracutaneous site involved, followed by the lungs. Ocular JXG is nearly always unilateral and develops in less than 0.5% of patients. Approximately 40% of patients with ocular JXG, however, have multiple cutaneous lesions at the time of diagnosis.
Juvenile xanthogranuloma (JXG) is a relatively common entity and is the most common form of non-Langerhans cell histiocytic disorder of childhood., It is estimated that in 75% of cases, lesions appear during the first year of life, with >15-20% of patients having lesions at birth. JXG is rare in adults, with a peak incidence in the late twenties to thirties. The majority of adult patients have solitary lesions. Typically, the clinical presentation consists of solitary or multiple yellow-orange-brown firm papules or nodules. The most common locations are the face, neck, and upper torso. Oral lesions are rare and often occur as a yellow nodule on the lateral aspects of the tongue. Oral lesions can also arise on the gingival, buccal mucosa, and midline hard palate and may ulcerate and bleed. Cutaneous lesions are usually asymptomatic, and most lesions spontaneously involute over the course of several years. Although occurring rarely, ocular involvement is the most common extracutaneous site involved, followed by the lungs. Ocular JXG is nearly always unilateral and develops in less than 0.5% of patients. Approximately 40% of patients with ocular JXG, however, have multiple cutaneous lesions at the time of diagnosis.
Juvenile xanthogranulomas (JXGs) são doenças benignas incomuns que pertencem a uma categoria maior de non‑Langerhans cell histiocytoses. Eles geralmente se apresentam como um ou mais nódulos vermelhos ou amarelados, frequentemente localizados na cabeça ou no pescoço. A maioria dos JXGs surge ao nascer ou no primeiro ano de vida. Embora seja raro, podem, ocasionalmente, envolver áreas além da pele; o comprometimento ocular deve ser monitorado, conforme a literatura existente. Geralmente, os JXGs cutâneos desaparecem espontaneamente e não requerem tratamento.
Juvenile xanthogranulomas (JXGs) are uncommon, benign diseases that are part of a larger category of non-Langerhans cell histiocytoses. They typically show up as one or more red or yellowish lumps, often found on the head or neck. Most JXGs develop either at birth or within the first year of life. While it's unusual, sometimes they can affect areas beyond the skin, with eye involvement being something to watch for according to existing literature. Generally, JXGs on the skin go away on their own and typically don't need treatment.
Juvenile xanthogranulomas (JXGs) are uncommon, benign diseases that are part of a larger category of non-Langerhans cell histiocytoses. They typically show up as one or more red or yellowish lumps, often found on the head or neck. Most JXGs develop either at birth or within the first year of life. While it's unusual, sometimes they can affect areas beyond the skin, with eye involvement being something to watch for according to existing literature. Generally, JXGs on the skin go away on their own and typically don't need treatment.
A lesão ocular ocorre em até 10 % das pessoas com XGJ e pode comprometer a visão. Embora as lesões cutâneas desapareçam espontaneamente, as lesões oculares raramente melhoram sem intervenção e requerem tratamento.